St. Louis is an independent city separate from St. Louis County in the U.S. state of Missouri, located near the confluence of the Mississippi River and the Missouri River. St. Louis is the second largest city in Missouri, but is the largest metropolitan area in the state. Sometimes written as Saint Louis, the city is named for King Louis IX of France. St. Louis is famous for its multiple French and German influences as well as having a Victorian past.
As St. Louis entered the 20th century, it was the 4th largest city in the United States. Two major events held in this period, the 1904 World's Fair and 1904 Olympic Games, the first ever held in the United States, are of particular pride to St. Louisans. In the 21st century, St. Louis has transformed from a manufacturing and industrial economy into a globally known focus for research in medicine, biotechnology, and other sciences. The St. Louis region is home to 21 Fortune 1000 companies, nine of which are in the Fortune 500. The region is also home to some of the country's largest privately held corporations, including Enterprise Rent-A-Car, Graybar and Edward Jones.